Kanchan Bisht

Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2

This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.

Amyloid beta Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer's Disease

This study identifies lipid droplet formation in microglia as a mechanism linking amyloid-beta exposure to impaired phagocytosis in Alzheimer's disease, with DGAT2 as a therapeutic target.

Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible versus resistant male mice upon repeated social defeat

This study shows that a ketogenic diet promotes resistance to stress in mice by altering microglial morphology and lipid profiles in the hippocampus, with distinct effects in stress-susceptible and resistant mice.

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling

The paper identifies capillary-associated microglia (CAMs) and shows they regulate vascular structure and function via PANX1-P2RY12 signaling.

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Low maternal omega-3 fatty acid intake impairs microglia-mediated synaptic refinement via the 12-HETE pathway in the developing brain.