LDB1-dependent enhancer connectivity defines T-cell leukemia identities and masks metabolic vulnerabilities
Rahul S. Bhansali, Juan Sebastian Long, Petri Pölönen, Tomoya Isobe, Siqing Wang, Shuo Zhang, Zhuangzhuang Geng, Ahnaf Tausif, Mariah C. Antopia, Nicholas G. Aboreden, Sarah J. Skuli, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Kai Tan, , Gerd A. Blobel
The paper identifies LDB1-dependent enhancer connectivity as critical for T-cell leukemia subtypes and reveals a metabolic vulnerability exploitable by statins.
bioRxiv · Jun 30, 2026 · PreprintCancer Biology