Nicholas G. Aboreden

LDB1-dependent enhancer connectivity defines T-cell leukemia identities and masks metabolic vulnerabilities

The paper identifies LDB1-dependent enhancer connectivity as critical for T-cell leukemia subtypes and reveals a metabolic vulnerability exploitable by statins.

Dynamics of microcompartment formation at the mitosis-to-G1 transition

The paper uses Region Capture Micro-C to study microcompartment formation during mitosis-to-G1 transition, finding they form in prometaphase and are influenced by chromatin compaction and loop extrusion.

Single-stranded DNA binding proteins are essential components of the architectural LDB1 protein complex

This study shows SSBP3 is essential for LDB1-mediated chromatin looping and transcription, and stabilizes LDB1 homodimers.

Cis-regulatory chromatin contacts form de novo in the absence of loop extrusion

This study shows that most cis-regulatory element contacts and gene transcription after mitosis occur without loop extrusion, though some loops depend on NIPBL.

LDB1 establishes multi-enhancer networks to regulate gene expression

This study shows LDB1 directly promotes enhancer-promoter loops and organizes multi-enhancer networks to activate transcription, independent of CTCF, cohesin, or YY1.

ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression

The paper identifies ZNF410 as a highly specific transcriptional activator in erythroid cells that regulates CHD4 and fetal hemoglobin expression.