Cortical hyperexcitability drives dying forward ALS symptoms and pathology in mice
Mouna Haidar, Aida Viden, Brittany Cuic, Taide Wang, Marius Rosier, Doris Tomas, Samuel A. Mills, A. Cole, Elvan Djouma, Sophia J. Luikinga, Valeria Rytova, Samantha K. Barton, David G. Gonsalvez, Lucy M. Palmer, Catriona McLean, , Bradley J. Turner
This study shows that cortical hyperexcitability in mice leads to ALS-like motor symptoms and pathology through a dying-forward mechanism.
bioRxiv · Aug 13, 2021 · PreprintNeuroscience