Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis
Jooho Chung, Mounica Vallurupalli, Sarah Noel, Gail Schor, YuhJong Liu, Celeste Nobrega, Jonathan Perera, Ewa Wrona, Margaret Hu, Yunkang Lin, David Wei Wu, Maria Saberi, Ilario Scapozza, Aidan Cruickshank, Elliot C. Woods, , Robert T. Manguso
The paper identifies CD43 as a glyco-immune checkpoint that inhibits human macrophage phagocytosis, showing that O-linked glycosylation and sialylation pathways regulate this process in AML.
bioRxiv · May 5, 2025 · PreprintCancer Biology