Author

Margaret Hu

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:long-read sequencing· 1 Assay:scRNA-seq· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Gail SchoriD· 2 shared Mounica VallurupalliiD· 2 shared Todd R. GolubiD· 2 shared Aidan Cruickshank· 1 shared Andrea Navarro TorresiD· 1 shared Andrew Mark BrunneriD· 1 shared Anisha LaumasiD· 1 shared Ashwin V. KammulaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

Gail SchorORCID

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Author profile →

2 papers

Recent·Most cited

Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation

Xi Dawn Chen, Manson Jim, Mounica Vallurupalli, Kai Cao, Andrea Navarro Torres, Jing Wesley Leong, Yifan Zhang, David Wollensak, Qiyu Gong, Jing Sun, Mehdi Borji, Gail Schor, Sofia Mrowka, Margaret Hu, Anisha Laumas, , Fei Chen

The paper introduces SPICE, a framework that uses splicing assays and generative design to create cell-specific gene regulation elements for research and therapy.

bioRxiv · Nov 5, 2025 · PreprintMolecular Biology

Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis

Jooho Chung, Mounica Vallurupalli, Sarah Noel, Gail Schor, YuhJong Liu, Celeste Nobrega, Jonathan Perera, Ewa Wrona, Margaret Hu, Yunkang Lin, David Wei Wu, Maria Saberi, Ilario Scapozza, Aidan Cruickshank, Elliot C. Woods, , Robert T. Manguso

The paper identifies CD43 as a glyco-immune checkpoint that inhibits human macrophage phagocytosis, showing that O-linked glycosylation and sialylation pathways regulate this process in AML.

bioRxiv · May 5, 2025 · PreprintCancer Biology