Daniel J. DeAngelo

This paper uses Dynamic BH3 Profiling to predict clinical outcomes in AML by assessing drug-induced apoptotic priming in patient samples.

The paper identifies CD43 as a glyco-immune checkpoint that inhibits human macrophage phagocytosis, showing that O-linked glycosylation and sialylation pathways regulate this process in AML.

The paper identifies TERT rare variants in MDS patients, showing shorter telomeres, younger age at diagnosis, and worse survival, suggesting their role in MDS pathogenesis and transplant outcomes.