ImmunologybioRxivPreprint
Structural basis for constitutive activation and CXCL1 recognition of human herpesvirus 8-encoded G protein-coupled receptor KSHV-GPCR
Aijun Liu, Yezhou Liu, Clàudia Llinàs del Torrent Masachs…·Richard D. Ye
This study determines the cryo-EM structures of KSHV-GPCR in complex with Gi and CXCL1, revealing structural mechanisms of constitutive activation and ligand binding.