De novo designed bifunctional proteins for targeted protein degradation
Bram Mylemans, Bogusława Korona, Amanda M. Acevedo‐Jake, Ailsa MacRae, Thomas A. Edwards, Danny T Huang, Andrew John Wilson, Laura S. Itzhaki, Derek N. Woolfson
This paper designs de novo bifunctional proteins for targeted protein degradation, demonstrating their ability to degrade BCL-xL in cells.
Journal of the American Chemical Society · Aug 5, 2026Peer-reviewedSynthetic Biology