Bram Mylemans

This paper designs de novo bifunctional proteins for targeted protein degradation, demonstrating their ability to degrade BCL-xL in cells.

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

The paper demonstrates the use of coiled-coil scaffolds to enable targeted protein degradation by integrating target-binding and degradation motifs into single-polypeptide constructs.

The paper designs synthetic proteins by deriving sequence-to-structure rules from coiled-coil tetramers and validates them through experimental methods.

The paper designs and crystallizes two symmetric nine-bladed propeller proteins, which adopt pseudo-symmetric eight-fold conformations with distorted termini.