Thomas A. Edwards

This paper designs de novo bifunctional proteins for targeted protein degradation, demonstrating their ability to degrade BCL-xL in cells.

The paper demonstrates the use of coiled-coil scaffolds to enable targeted protein degradation by integrating target-binding and degradation motifs into single-polypeptide constructs.

This study identifies RNA-binding targets of the HOW(S) protein in Drosophila spermatogenesis using RIP-seq, revealing novel transcripts and motif preferences.

This paper identifies two RAS-binding Affimer proteins that inhibit RAS function and reveal a novel druggable SII/3 pocket.