Andrew John Wilson

De novo designed bifunctional proteins for targeted protein degradation

This paper designs de novo bifunctional proteins for targeted protein degradation, demonstrating their ability to degrade BCL-xL in cells.

Expanding all-α-helical protein space through rational computational design

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

Bora Bridges Aurora-A Activation and Substrate Recognition of PLK1

This study presents structural models of the Aurora-A/Bora and Aurora-A/Bora/PLK1 complexes, revealing how Bora bridges Aurora-A activation and PLK1 substrate recognition.

Coiled-coil scaffolds for Targeted Protein Degradation

The paper demonstrates the use of coiled-coil scaffolds to enable targeted protein degradation by integrating target-binding and degradation motifs into single-polypeptide constructs.