Bogusława Korona

This paper designs de novo bifunctional proteins for targeted protein degradation, demonstrating their ability to degrade BCL-xL in cells.

The paper demonstrates the use of coiled-coil scaffolds to enable targeted protein degradation by integrating target-binding and degradation motifs into single-polypeptide constructs.

The paper shows that the Delta C2 domain β1-2 loop is essential for phospholipid binding and robust Notch signaling in Drosophila.

The paper identifies a kinase-dependent checkpoint involving Rio1, Nob1, and Pno1 that prevents immature ribosomes from entering the translating pool, ensuring proper maturation and preventing fidelity defects.