BiochemistryJournal of Molecular BiologyPeer-reviewed
An intrinsically disordered region of histone demethylase KDM5A activates catalysis through interactions with the nucleosomal acidic patch and DNA
Ali Palla, Chien-Chu Lin, Michael J. Trnka…·Danica Galonić Fujimori
This study identifies an intrinsically disordered region in KDM5A that binds the nucleosome's acidic patch and DNA, enabling catalytic activity through multivalent interactions.