An image-based CRISPR screen reveals splicing-mediated control of HP1α condensates
Matthew Man-Kin Wong, Shaopu Zhou, Chris Carpenter, Raeline Valbuena, Monika Priyadarshini, Aishwarya Arya, Aoon Rizvi, Catherine Carswell-Crumpton, Amelie Wileveau, Gabriel López-López, Josh Tycko, David Yao, Kaitlyn K. Spees, Jason C. Maynard, Michael Cory Bassik, , Serena Sanulli
The paper uses an image-based CRISPR screen to show splicing regulates HP1α condensates through RNA-chromatin interactions, affecting heterochromatin organization and stress response genes.
bioRxiv · Sep 21, 2025 · PreprintGenetics