Author

Chris Carpenter

Arc Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Hani GoodarziiD· 3 shared Aishwarya Arya· 1 shared Alan H. BaikiD· 1 shared Albertas NavickasiD· 1 shared Amelie WileveauiD· 1 shared Ankur GargiD· 1 shared Aoon RizviiD· 1 shared Augustinus G. HaribowoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

Hani GoodarziORCID

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3 papers

Recent·Most cited

Systemic hypoxia suppresses solid tumor growth

Ayush D. Midha, Brandon T.L. Chew, Bong Gun Choi, Jung Min Suh, Chris Carpenter, Alan H. Baik, Tej Joshi, Skyler Y. Blume, Augustinus G. Haribowo, Pedro Ruivo, Will Flanigan, Ankur Garg, Daniel Zhang, Vishvak Subramanyam, Rebecca Shuere, , Isha H. Jain

This study shows systemic hypoxia reduces solid tumor growth across multiple cancer types without resistance, through purine metabolism suppression and can be pharmacologically induced.

bioRxiv · Feb 10, 2026 · PreprintCancer Biology

An image-based CRISPR screen reveals splicing-mediated control of HP1α condensates

Matthew Man-Kin Wong, Shaopu Zhou, Chris Carpenter, Raeline Valbuena, Monika Priyadarshini, Aishwarya Arya, Aoon Rizvi, Catherine Carswell-Crumpton, Amelie Wileveau, Gabriel López-López, Josh Tycko, David Yao, Kaitlyn K. Spees, Jason C. Maynard, Michael Cory Bassik, , Serena Sanulli

The paper uses an image-based CRISPR screen to show splicing regulates HP1α condensates through RNA-chromatin interactions, affecting heterochromatin organization and stress response genes.

bioRxiv · Sep 21, 2025 · PreprintGenetics

Discovery of a tRNA-regulatory transcription factor that suppresses breast cancer metastasis

Siyu Chen, Daniel Markett, Mehran Karimzadeh, Yikai Luo, Matvei Khoroshkin, Bariş Boyraz, Sean Bong Lee, Chris Carpenter, Phi T. Nguyen, Kristle Garcia, Tanvi V. Joshi, Charlotte A. Martin, Benjamin Hänisch, Henrik Molina, Sohail F. Tavazoie, , Hani Goodarzi

The paper identifies ZZEF1 as a tRNA-specific transcription factor that suppresses breast cancer metastasis by regulating tRNA-LysUUU expression and affecting codon-specific translation.

bioRxiv · Apr 26, 2025 · PreprintGenomics