Cell migration sculpts evolutionary dynamics favouring therapy resistance in lung cancer
Ajay Bhargava, Xiao Fu, Sasha Bailey, Yutaka Naito, Hamid Mohammadi, Robert E. Hynds, Steven Hooper, Dhruva Biswas, Alix Le Marois, Sunil Kumar, Yuriy Alexandrov, P. M. W. French, James McGinty, Paul A. Bates, Charles Swanton, Erik A. Sahai
This study shows that cell migration and stromal fibroblasts influence subclone competition in lung cancer, promoting therapy resistance through increased cell mixing.
bioRxiv · Sep 15, 2025 · PreprintCancer Biology