Sunil Kumar

This paper develops a CRISPR-engineered FRET biosensor to study PARP trapping dynamics in ovarian cancer cells and identifies reduced trapping in PARPi-resistant models.

This study shows that cell migration and stromal fibroblasts influence subclone competition in lung cancer, promoting therapy resistance through increased cell mixing.

The paper introduces VP-CLEM-Kit, a cost-effective SR-vCLEM pipeline for visual proteomics, achieving 5-fold resolution improvement at 7-fold lower cost.

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.