Author

Xiao Fu

The Francis Crick InstituteORCID 0000-0002-8611-891XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Erik A. SahaiiD· 2 shared Sasha Bailey· 2 shared Steven HooperiD· 2 shared Ajay Bhargava· 1 shared Alexandrine CarminatiiD· 1 shared Alix Le MaroisiD· 1 shared Amna MatlyiD· 1 shared Amy L. BowesiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

Erik A. SahaiORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 23, 2025

Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma

Karin Schlegelmilch, Viola Hollek, Steven Hooper…·Erik A. Sahai

This study shows that cooperative and antagonistic interactions between sub-clones in melanoma allow multiple resistance mechanisms to coexist, and identifies GSK-J4 as a potential therapeutic target.

DOI 10.1101/2025.10.23.684170

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 15, 2025

Cell migration sculpts evolutionary dynamics favouring therapy resistance in lung cancer

Ajay Bhargava, Xiao Fu, Sasha Bailey…·Erik A. Sahai

This study shows that cell migration and stromal fibroblasts influence subclone competition in lung cancer, promoting therapy resistance through increased cell mixing.

DOI 10.1101/2025.09.15.675999

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 5, 2025

Epithelial Plasticity and an Immune Suppressive Microenvironment Underpin Tumour Budding in Colorectal Cancer

Phimmada Hatthakarnkul, Natalie C. Fisher, Leonor Schubert Santana…·Joanne Edwards

This study identifies TNF- and TGF-β signaling as drivers of tumour budding in CRC, linked to poor prognosis and an immunosuppressive microenvironment.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky