Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells
Mufeng Hu, Anna Weldy, Isabella Lovalvo, Erin A. Akins, Saket Jain, Alex R. Chang, Ankita Sati, Meeki Lad, Austin Lui, Akhil Rajidi, Ameya Kothekar, Erika A. Ding, Sanjay Kumar, Manish Kumar Aghi
The paper identifies ACP1 and AURKB as regulators of cortactin-driven actin remodeling in glioblastoma invasion using CRISPRi screens in 3D hydrogels.
bioRxiv · Jan 20, 2025 · PreprintCancer Biology