Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor
Chiyo Suno-Ikeda, Ryo Nishikawa, Riko Suzuki, Shun Yokoi, Seiya Iwata, Tomoyo Takai, Takaya Ogura, Mika Hirose, Akihisa Tokuda, Risako Katamoto, Akitoshi Inoue, Eri Asai, Ryoji Kise, Yukihiko Sugita, Takayuki Kato, , Ryoji Suno
This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.
Nature Communications · Oct 28, 2025Peer-reviewedBiophysics