Hideki Kandori

Multi-modal ion-transport function of potassium channelrhodopsins

This study demonstrates that potassium channelrhodopsins function as H+ pumps and channels, with their activity modulated by light and environmental ions.

Self-regenerating opsin from reef-building coral

This paper identifies a coral opsin, AtAntho2c, that can autonomously regenerate its inactive state through thermal isomerization of retinal, enabling repeated light responses without exogenous retinal.

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.

Structural basis for color tuning and passive ion conductance in red-shifted pump-fold channelrhodopsin ChR024

This study presents cryo-EM structures of ChR024, revealing its color-tuning mechanism and transition from a proton pump to a light-gated channel.

Light-harvesting by antenna-containing rhodopsins in pelagic Asgard archaea

The paper reports light energy transfer from hydroxylated carotenoids to heimdallarchaeial rhodopsins in marine archaea, showing light-harvesting capabilities in archaea similar to bacterial rhodopsins.

Optogenetic manipulation of second messengers in neurons and cardiomyocytes with microbial rhodopsins and adenylyl cyclase

The paper demonstrates the use of microbial rhodopsins and adenylyl cyclases to control second messengers in zebrafish neurons and cardiomyocytes, revealing their roles in locomotion and cardiac function.

Remote control of neural function by X-ray-induced scintillation

This paper demonstrates the use of X-ray-induced scintillation to remotely control neural function in mice, achieving bidirectional modulation of behavior through optogenetic activation and inhibition.

High-sensitivity vision restoration via ectopic expression of chimeric rhodopsin in mice

The paper demonstrates that ectopic expression of chimeric rhodopsin in mice restores dim-light vision and prevents retinal degeneration.

Toward Machine Learning-based Data-driven Functional Protein Studies: Understanding Colour Tuning Rules and Predicting the Absorption Wavelengths of Microbial Rhodopsins

The paper uses machine learning to predict and understand the absorption wavelengths of microbial rhodopsins by analyzing sequence and functional data.