West Nile virus capsid protein promotes viral replication and pathogenesis through PKCα-dependent lamin phosphorylation and nuclear deformation
Keisuke Maezono, Passawat Thammahakin, Michiyo Kataoka, Tadaki Suzuki, Haruto Eguchi, Duong Thi Ngoc Thuy, Toshiro Yamaguchi, Akira Ota, Yukari Itakura, Koshiro Tabata, Hirofumi Sawa, Kentaro Yoshii, Hiroaki Kariwa, Shintaro Kobayashi
This paper shows that WNV capsid protein causes nuclear deformation via PKCα-dependent lamin phosphorylation, which supports viral replication and disease.
bioRxiv · Jul 23, 2026 · PreprintMicrobiology