Ablation of GM3 Gangliosides in cardiomyocytes modestly impacts heart size but does not protect the murine heart against ischemia reperfusion injury
Yow Keat Tham, Daniel G. Donner, Gunes S. Yildiz, Helen Kiriazis, Aya Matsumoto, Kyah Grigolon, Emma I. Masterman, Natalie A. Mellett, Teleah G. Belkin, Jieting Luo, Akshima Dogra, Aascha Brown, Peter J. Meikle, Julie R. McMullen
This study shows that removing GM3 gangliosides in cardiomyocytes slightly reduces heart size but does not protect against ischemia-reperfusion injury.
bioRxiv · Jul 18, 2026 · PreprintPhysiology