Author

Aascha Brown

Baker Heart and Diabetes InstituteORCID 0000-0002-6931-3502Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Daniel G. DonneriD· 3 shared Helen KiriazisiD· 3 shared Julie R. McMulleniD· 2 shared Akshima Dogra· 1 shared Alexander Ruvantha PintoiD· 1 shared Andrew James MurphyiD· 1 shared Arpeeta SharmaiD· 1 shared Auriane DrackiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersPhysiology

Daniel G. DonnerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ablation of GM3 Gangliosides in cardiomyocytes modestly impacts heart size but does not protect the murine heart against ischemia reperfusion injury

Yow Keat Tham, Daniel G. Donner, Gunes S. Yildiz, Helen Kiriazis, Aya Matsumoto, Kyah Grigolon, Emma I. Masterman, Natalie A. Mellett, Teleah G. Belkin, Jieting Luo, Akshima Dogra, Aascha Brown, Peter J. Meikle, Julie R. McMullen

This study shows that removing GM3 gangliosides in cardiomyocytes slightly reduces heart size but does not protect against ischemia-reperfusion injury.

bioRxiv · Jul 18, 2026 · PreprintPhysiology

Inhibition of Gasdermin D by Disulfiram Attenuates Cardiac Inflammation and Fibrosis following Ischaemia Reperfusion Injury

Judy S.Y. Choi, Mehnaz Pervin, Helen Kiriazis, Parvin Yavari, Aascha Brown, Man K.S. Lee, Andrew James Murphy, Daniel G. Donner, James Edward Vince, Arpeeta Sharma, Judy B. de Haan

This paper shows that Disulfiram reduces cardiac inflammation and fibrosis after heart attack by inhibiting the GSDMD pathway.

bioRxiv · Mar 12, 2026 · PreprintImmunology

Single-cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosis

Crisdion Krstevski, Gabriella E. Farrugia, Ian Hsu, Malathi S.I. Dona, Taylah L. Gaynor, Charles D. Cohen, Rebecca L. Harper, Thomas I. Harrison, Bethany Claridge, Auriane Drack, Patrick M. Lelliott, Helen Kiriazis, Aascha Brown, Julie R. McMullen, Daniel G. Donner, , Alexander Ruvantha Pinto

This study uses single-cell multiomic analysis to identify transcriptional circuits driving non-ischemic cardiac fibrosis in mouse and human hearts, showing reversibility of fibrosis-related changes.

bioRxiv · May 9, 2024 · PreprintCell Biology