Helen Kiriazis

This study shows that biological sex and nitric oxide synthase inhibition lead to different cardiac responses to cardiometabolic stress in older mice, resulting in distinct HFpEF-like or HFrEF-like phenotypes.

This study shows that removing GM3 gangliosides in cardiomyocytes slightly reduces heart size but does not protect against ischemia-reperfusion injury.

This paper shows that Disulfiram reduces cardiac inflammation and fibrosis after heart attack by inhibiting the GSDMD pathway.

This study shows that impairing polymerase gamma activity in cardiomyocytes leads to mtDNA instability, activates the integrated stress response, and causes severe cardiomyopathy with hepatopathy in mice.

This study investigates the role of B55α in cardiac transcriptome regulation, finding sex-specific effects on cardiac fibrosis and gene expression.

This study uses single-cell multiomic analysis to identify transcriptional circuits driving non-ischemic cardiac fibrosis in mouse and human hearts, showing reversibility of fibrosis-related changes.

This study demonstrates that long-term tissue-specific Cas9 expression in mice does not cause detrimental health effects or metabolic changes, supporting its use for gene-specific studies.