RNA degradation by DIS3 is a necessary step in the resolution of backtracked transcription complexes
Elin Enervald, Shruti Jain, Marcel Tarbier, Indranil Sinha, Akshit Jain, Pratibha Banerjee, Jordi Planells, Toni McHugh, Neus Visa
This paper shows that DIS3's 3-5 exoribonuclease activity degrades backtracked RNA, resolving stalled RNAPII complexes and enabling transcription elongation.
Cell Reports · Aug 22, 2026Peer-reviewedMolecular Biology