Author

Toni McHugh

University of EdinburghORCID 0000-0002-5212-3868Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christos SpanosiD· 2 shared David A. KellyiD· 2 shared A. Arockia Jeyaprakash· 1 shared Adrian Peter BirdiD· 1 shared Akshit Jain· 1 shared Asma Abdullah Abdulwahab Al-MurtadhaiD· 1 shared Axel ImhofiD· 1 shared Bethan Medina‐PritchardiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

Christos SpanosORCID

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3 papers

Recent·Most cited

Molecular BiologyCell ReportsPeer-reviewedAug 22, 2026

RNA degradation by DIS3 is a necessary step in the resolution of backtracked transcription complexes

Elin Enervald, Shruti Jain, Marcel Tarbier…·Neus Visa

This paper shows that DIS3's 3-5 exoribonuclease activity degrades backtracked RNA, resolving stalled RNAPII complexes and enabling transcription elongation.

DOI 10.1016/j.celrep.2026.117886

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintOct 27, 2025

Tetramerisation governs SALL transcription factor function in development and disease

Sara Giuliani, Kashyap Chhatbar, Martin A. Wear…·Adrian Peter Bird

This study identifies tetramerisation as essential for SALL transcription factor function, showing its role in DNA binding and linking it to developmental disorders.

DOI 10.1101/2025.10.27.684836

mouseexperimental assay

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Cell BiologySciencePeer-reviewedSep 5, 2024

PLK1-Mediated Phosphorylation Cascade Activates the Mis18 Complex to Ensure Centromere Inheritance

Pragya Parashara, Bethan Medina‐Pritchard, Maria Alba Abad…·A. Arockia Jeyaprakash

The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.

38 citationstop 2%

experimental assaybiophysical modeling

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