Marcel Tarbier

This paper shows that DIS3's 3-5 exoribonuclease activity degrades backtracked RNA, resolving stalled RNAPII complexes and enabling transcription elongation.

CycleVI isolates cell cycle variation in scRNA-seq data using a deep generative model, improving the resolution of biological processes and drug response signals.

The paper studies microRNA and target expression variation in mouse embryonic stem cells using genetic perturbation and single-cell RNA-seq, finding four co-expression groups and mixed effects on target variation.

GEMLI predicts cell lineages from scRNA-seq data without lineage tracing, identifying heritable gene expression and cell fate decisions in various contexts.

The paper identifies >80,000 gene pairs with intrinsic covariance in mouse embryonic stem cells, showing nuclear organization and protein interactions drive transcript covariances.