Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models
Cynthia D. Jesudason, Claudia Rangel‐Barajas, Colin J Beach, Daniel E. Beck, Isaac Caballero-Floran, Brent Clayton, Lais Da Silva, Juliane C David, Suzanne Doolen, Alexandra N. Faulkner, Adam K. Hamdani, Hasi Huhe, Kevin Huynh, Ryan D. Imhoff, June Javens‐Wolfe, , Timothy I. Richardson
This study identifies SHIP1 ligands with brain exposure and in vivo activity in Alzheimer's models, showing target engagement and reduced neuroinflammation.
Journal of Medicinal Chemistry · Apr 30, 2026Peer-reviewedPharmacology & Toxicology