Author

Ryan D. Imhoff

Indiana University School of MedicineORCID 0000-0002-8510-8437Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam K. HamdaniiD· 1 shared Adrian L. OblakiD· 1 shared Alan David Palkowitz· 1 shared Alexandra N. Faulkner· 1 shared Alisha DhimaniD· 1 shared Andrew D. MesecariD· 1 shared Brent ClaytoniD· 1 shared Brittany L. Allen-PeterseniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPharmacology & Toxicology

Adam K. HamdaniORCID

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2 papers

Recent·Most cited

Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3

Nagabhushana C. Beeralingappa, Mengyao Lu, Rishi S. Patel, Nipuni M. Pannala, Alisha Dhiman, Brittany N. Heil, Ryan D. Imhoff, Emily G. Smith, Mei B Bahler, Haley L Marsden, Brittany L. Allen-Petersen, Mike Wendt, Chittaranjan Das, Daniel Patrick Flaherty

This study identifies and optimizes a chloroacetamide scaffold as a covalent inhibitor for UCHL3, supported by structural and biochemical validation.

bioRxiv · May 29, 2026 · PreprintPharmacology & Toxicology

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models

Cynthia D. Jesudason, Claudia Rangel‐Barajas, Colin J Beach, Daniel E. Beck, Isaac Caballero-Floran, Brent Clayton, Lais Da Silva, Juliane C David, Suzanne Doolen, Alexandra N. Faulkner, Adam K. Hamdani, Hasi Huhe, Kevin Huynh, Ryan D. Imhoff, June Javens‐Wolfe, , Timothy I. Richardson

This study identifies SHIP1 ligands with brain exposure and in vivo activity in Alzheimer's models, showing target engagement and reduced neuroinflammation.

Journal of Medicinal Chemistry · Apr 30, 2026Peer-reviewedPharmacology & Toxicology