Author

Andrew D. Mesecar

Purdue University West LafayetteORCID 0000-0002-1241-2577Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adrian L. OblakiD· 2 shared Bruce T. LambiD· 2 shared Kratika SinghaliD· 2 shared Adam J. CarriD· 1 shared Adam K. HamdaniiD· 1 shared Alan David Palkowitz· 1 shared Alexandra N. Faulkner· 1 shared Andy Po‐Yi TsaiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPharmacology & Toxicology

Adrian L. OblakORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewedApr 30, 2026

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models

Cynthia D. Jesudason, Claudia Rangel‐Barajas, Colin J Beach…·Timothy I. Richardson

This study identifies SHIP1 ligands with brain exposure and in vivo activity in Alzheimer's models, showing target engagement and reduced neuroinflammation.

1 citation

mouseproteomics

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BiochemistrybioRxivPreprintApr 25, 2025

One-carbon metabolism enzyme Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration

Sarah C. Stanhope, Kratika Singhal, Nicolás M. Morato…·Vikki Marie Weake

1 citation

Drosophilaexperimental assay

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NeuroscienceImmunityPeer-reviewedSep 1, 2023

Genetic Variants of Phospholipase C-γ 2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimers Disease

Andy Po‐Yi Tsai, Chuanpeng Dong, Peter Bor‐Chian Lin…·Gary E. Landreth

The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.

71 citationstop 2%

mousestatistical model

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