Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma
Nicole M. Marsh, Melissa J. S. MacEwen, Jane Chea, Heidi L. Kenerson, Albert A. Kwong, Timothy M. Locke, Francisco Javier Miralles, Tanmay Sapre, Natasha Gozali, Madeleine L. Hart, Theo K. Bammler, James W. MacDonald, Lucas B. Sullivan, Gunes Ekin Atilla‐Gokcumen, Shao‐En Ong, , Yasemin Sancak
This study shows that mitochondrial calcium signaling regulates branched-chain amino acid catabolism and the urea cycle in fibrolamellar carcinoma through transcriptional control of metabolic genes.
Science Advances · May 28, 2025Peer-reviewedCell Biology