Lucas B. Sullivan

This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.

This study identifies two adaptive mechanisms in SDH-deficient cancer cells to overcome aspartate limitation and improve proliferative fitness.

The paper shows that SDH loss reduces aspartate and increases succinate, inhibiting ATCase and impairing pyrimidine synthesis, leading to replication stress and ATR sensitivity.

The paper investigates how amino acid limitation affects translation by analyzing ribosome stalling and the role of RQC pathways and RNF14 in response to arginine depletion.

This study identifies de novo pyrimidine synthesis as a metabolic vulnerability in recurrent breast cancer cells that suppresses ferroptosis, with DHODH inhibition selectively targeting these cells.

The paper identifies cytokine and metabolite networks that regulate T cell fate at the human maternal-fetal interface, showing how they restrain T cells in an antigen-independent manner.

This study shows that mitochondrial calcium signaling regulates branched-chain amino acid catabolism and the urea cycle in fibrolamellar carcinoma through transcriptional control of metabolic genes.

This study identifies the metabolic role of serum in cell culture by showing that albumin-bound lipids are essential for cancer cell proliferation and can replace fetal bovine serum.