Madeleine L. Hart

This study shows that lipoic acid exists in two distinct cellular pools with different functions, and supplementation increases free LA without restoring mitochondrial function.

This study identifies two adaptive mechanisms in SDH-deficient cancer cells to overcome aspartate limitation and improve proliferative fitness.

The paper shows that SDH loss reduces aspartate and increases succinate, inhibiting ATCase and impairing pyrimidine synthesis, leading to replication stress and ATR sensitivity.

This study identifies AASDHPPT as a mitochondrial PPTase essential for mtFAS and oxidative function, with human variants linked to pathogenic effects.

This study shows that mitochondrial calcium signaling regulates branched-chain amino acid catabolism and the urea cycle in fibrolamellar carcinoma through transcriptional control of metabolic genes.