Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness
Aishwarya Pawar, Patrick Somers, Aleena Alex, Jason Grana, Victoria K. Feist, Subin S. George, Sapana S. Jalnapurkar, Charles Antony A, Roman Verner, Sanese K. White-Brown, Mohit Khera, Maria Saraí Mendoza-Figueroa, Kathy Fange Liu, Jennifer J. D. Morrissette, Sandeep K. Gurbuxani, Vikram R. Paralkar
This study identifies PHF6 and PHIP as a chromatin complex that represses AML stemness, showing their functional relationship and the impact of their mutations.
bioRxiv · Nov 29, 2024Cancer Biology