Maria Saraí Mendoza-Figueroa

This study shows that impaired 5'ETS pre-rRNA cleavage disrupts nucleolar organization, leading to mislocalization of RNA and proteins, and broader nuclear architecture changes.

This study identifies PHF6 and PHIP as a chromatin complex that represses AML stemness, showing their functional relationship and the impact of their mutations.

The paper shows that IntS6 recruits PP2A to regulate transcription termination efficiency at specific genes, highlighting the phosphatase module's selective role in Integrator complex function.

This study shows that specific DDX3X mutants form hollow condensates, impairing catalytic activity and interacting differently with WT DDX3X and DDX3Y, which may explain sex-specific disease biases.