Author

Patrick Somers

University of PennsylvaniaORCID 0000-0002-5932-9236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Charles Antony AiD· 2 shared Subin S. GeorgeiD· 2 shared Vikram R. ParalkariD· 2 shared Aishwarya PawariD· 1 shared Aleena Alex· 1 shared Austen R. D. GanleyiD· 1 shared Chelsea L. ThorsheimiD· 1 shared Dexter J. Wu-Corts· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Charles Antony AORCID

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2 papers

Recent·Most cited

Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness

Aishwarya Pawar, Patrick Somers, Aleena Alex, Jason Grana, Victoria K. Feist, Subin S. George, Sapana S. Jalnapurkar, Charles Antony A, Roman Verner, Sanese K. White-Brown, Mohit Khera, Maria Saraí Mendoza-Figueroa, Kathy Fange Liu, Jennifer J. D. Morrissette, Sandeep K. Gurbuxani, Vikram R. Paralkar

This study identifies PHF6 and PHIP as a chromatin complex that represses AML stemness, showing their functional relationship and the impact of their mutations.

bioRxiv · Nov 29, 2024Cancer Biology

Control of Ribosomal RNA Synthesis by Hematopoietic Transcription Factors

Charles Antony A, Subin S. George, Justin Blum, Patrick Somers, Chelsea L. Thorsheim, Dexter J. Wu-Corts, Yuxi Ai, Long Gao, Kaosheng Lv, Michel G. Tremblay, Tom Moss, Kai Tan, Jeremy E. Wilusz, Austen R. D. Ganley, Maxim Pimkin, Vikram R. Paralkar

The paper identifies cell-type-specific transcription factors that bind rDNA and regulate rRNA transcription, showing CEBPA's role in promoting Pol I occupancy and rRNA synthesis in myeloid progenitors.

Molecular Cell · Sep 15, 2022Peer-reviewedMolecular Biology