A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors.
Noelia Rodríguez-Iglesias, Iñaki Paris, Jorge Valero, Lorena Cañas‐Zabala, Alejandro Carretero, Klas Hatje, Jitao David Zhang, Christoph Patsch, Markus Britschgi, Simon Gutbier, Amanda Sierra
The paper identifies two compounds, trifluoperazine and deoxytubercidin, as novel microglial phagocytosis inhibitors using high-throughput screening and in vivo validation.
Glia · Nov 4, 2024Peer-reviewedNeuroscience