Author

Christoph Patsch

F. Hoffmann-La Roche AGORCID 0000-0003-4224-3249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alejandro Carretero· 1 shared Amanda SierraiD· 1 shared Anne SpangiD· 1 shared Benjamin HaleyiD· 1 shared Carolina Hager· 1 shared Christian WeileiD· 1 shared Erich KolleriD· 1 shared Filip RoudnickyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Alejandro Carretero

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedJun 30, 2025

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular ASO activity

Liza Malong, Jessica Roskosch, Carolina Hager…·Filip Roudnicky

The paper uses a CRISPR/Cas9 screen to identify genes modulating ASO activity, revealing AP1M1 and TBC1D23 as key regulators of endosome-Golgi transport affecting ASO efficacy.

9 citations

humangenetic perturbation / CRISPR

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NeuroscienceGliaPeer-reviewedNov 4, 2024

A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors.

Noelia Rodríguez-Iglesias, Iñaki Paris, Jorge Valero…·Amanda Sierra

The paper identifies two compounds, trifluoperazine and deoxytubercidin, as novel microglial phagocytosis inhibitors using high-throughput screening and in vivo validation.

2 citations

mouseexperimental assay

𝕏 PostBluesky