Jorge Valero

The paper shows bone marrow-derived cells fuse with Bergmann glia in a mouse model of multiple sclerosis, forming heterokaryons with distinct donor and host nuclei.

This study identifies a proliferative-to-quiescent switch in microglial development and links it to epigenetic regulation and phagocytic function.

The paper investigates metabolic and transcriptional changes in microglia after phagocytosis, showing these adaptations sustain their functionality and regenerative properties.

The paper identifies two compounds, trifluoperazine and deoxytubercidin, as novel microglial phagocytosis inhibitors using high-throughput screening and in vivo validation.

This study shows that microglial phagocytosis dysfunction during stroke is prevented by rapamycin, highlighting its potential as a therapeutic target.

The paper introduces a new volumetric estimation method (TCS) and a tool (VolumestJ) for analyzing brain structure volumes from tissue sections, showing improved accuracy over the classical Cavalieris method.

The paper develops a triple co-culture model of neurons, microglia, and astrocytes to study Alzheimer's disease, showing reduced inflammation and synaptic loss in response to Aβ.

This study shows that microglial phagocytosis dysfunction in a genetic epilepsy model is linked to local neuronal activity, suggesting a role for neuronal activity in phagocytosis impairment.