Network inference at single-cell resolution reveals morphoregulatory divergence and multilayered buffering in limb evolution
Ana Alcaina-Caro, Ismael Sospedra-Arrufat, Virginie Tissières, Irepan Salvador-Martínez, Lucía Almorox, Julia Joanna Pawluk, Alejandro Díaz-Rueda, Ana Fernández-Miñán, Alicia Hurtado, Francisca Martínez Real, Dario Lupiáñez, Bárbara Pernaute, Axel Visel, Marco Osterwalder, Holger Heyn, , Javier Lopez-Rios
The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.
bioRxiv · Nov 9, 2026 · PreprintDevelopmental Biology