Marco Osterwalder

The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.

This study characterizes the electrophysiological maturation of human cardioids over three weeks, showing progressive changes in membrane potential, action potential amplitude, and duration.

The paper identifies essential cardiac enhancer modules and regulatory mechanisms governing heart development, revealing resilience in cis-regulatory architectures and the role of Hand2 upstream regulatory intervals.

The paper identifies hidden enhancers in mouse embryos that are not detected by conventional chromatin profiling methods, highlighting a significant gap in enhancer discovery.

The paper reconstructs a gene regulatory network directed by PBX1/2 and HAND2 in mouse limb development, showing their genetic interaction and tissue-specific function.

The paper identifies 14,000 human craniofacial enhancers across developmental stages and shows 56% are conserved in mice, providing cell type- and stage-specific activity profiles.

The paper identifies conserved notochord-specific enhancers of Brachyury/T/TBXT in vertebrates and shows their role in notochord expression and development.

The paper evaluates HAND2 gene regulatory networks in endocardial cells using single-cell transcriptomics to identify HAND2-dependent enhancers and their impact on cardiac morphogenesis.

The paper shows that sustained WT1 expression impairs cardiomyocyte maturation and leads to their transformation into epicardial cells in zebrafish.

The paper identifies bi-fated tendon-to-bone attachment cells regulated by shared enhancers and KLF transcription factors, revealing how these cells integrate chondrocyte and tenocyte features.

This study identifies a gene desert critical for Shox2 regulation and embryonic survival through enhancer networks in mouse development.