Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity
Anne-Sophie M. C. Marques, Ludwig G. Bauer, Tuan Anh Nguyen, Alejandro Gonzalez Orta, Jan L. Venne, Lai Cheng, Esra Balıkçı, Barr Tivon, Nir London, Stefan Kubicek, K. Huber
The paper develops NUDT5 degraders and shows NUDT5 has a non-enzymatic role in 6-TG toxicity, distinct from NUDT15.
bioRxiv · Mar 16, 2025 · PreprintCell Biology