Author

Lai Cheng

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Adam C. WilkinsoniD· 1 shared Adam J. MeadiD· 1 shared Alejandro Gonzalez Orta· 1 shared Anne-Sophie M. C. MarquesiD· 1 shared Barr Tivon· 1 shared Bethan PsailaiD· 1 shared Eleni LoukaiD· 1 shared Esra BalıkçıiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Adam C. WilkinsonORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Genome editing for treatment of JAK2 V617F-driven myeloproliferative neoplasms

Roman M. Doll, Yuqi Shen, Zoë C. Wong, Ramy Slama, Maria Greco, Lai Cheng, Eleni Louka, Weijiao Zhang, Yavor K. Bozhilov, Joseph C. Hamley, Adam C. Wilkinson, Bethan Psaila, Adam J. Mead, James O. J. Davies

This study uses CRISPR-Cas genome editing to selectively inactivate JAK2 V617F mutations in patient cells, showing that heterozygous cells are not oncogene addicted while homozygous cells are eradicated, suggesting genome editing as a potential treatment for MPNs.

bioRxiv · Dec 19, 2025 · PreprintCancer Biology

Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity

Anne-Sophie M. C. Marques, Ludwig G. Bauer, Tuan Anh Nguyen, Alejandro Gonzalez Orta, Jan L. Venne, Lai Cheng, Esra Balıkçı, Barr Tivon, Nir London, Stefan Kubicek, K. Huber

The paper develops NUDT5 degraders and shows NUDT5 has a non-enzymatic role in 6-TG toxicity, distinct from NUDT15.

bioRxiv · Mar 16, 2025 · PreprintCell Biology