Preimplantation factor (PIF) is an endogenous inhibitor of potassium channel KV1.3 regulating neutrophil function during pregnancy
Roland Immler, Wiebke Nadolni, Johanna M Franz, Annika Bertsch, Sebastian Baasch, Vasilios Aris Morikis, Aleksandra Kurova, Marco Borsò, Ignasi Forné, Ericka C M Itang, Johannes Müller, Monika Pruenster, Lou Martha Wackerbarth, Matteo Napoli, Ina Rohwedder, , Markus Sperandio
The paper identifies PIF as a placenta-derived peptide that inhibits KV1.3 channels in neutrophils, altering their function during pregnancy.
bioRxiv · Mar 23, 2026 · PreprintImmunology