Markus Sperandio

This study investigates how circadian immune regulation develops during postnatal life, finding that leukocyte rhythmicity and peripheral clocks mature progressively through development.

This study shows that integrin β1 is essential for mast cell positioning around arterioles and their vasoactive function, which are critical for leukocyte recruitment during inflammation.

This study investigates how stromal cells and macrophages interact during mycobacterial infection, revealing their roles in shaping immune responses and granuloma formation.

The paper presents a CITE-seq atlas of human neonatal immune development, identifying a 32-week gestational transition to interferon-primed immunity.

The paper identifies PIF as a placenta-derived peptide that inhibits KV1.3 channels in neutrophils, altering their function during pregnancy.

The paper identifies maternal neutrophils as a survival niche for Listeria monocytogenes, facilitating placental and fetal infection during pregnancy.

This study shows TRPM7 is essential for human CD4 T-cell activation and differentiation through Mg2+ dependent Ca2+ signaling and NFAT translocation.

The paper shows that alveolar macrophages recruit neutrophils to sites of nanoparticle deposition in the lung through motility, phagocytosis, and cytokine release.

This study identifies the eATP/P2X7R axis as a driver of nanoparticle-induced neutrophil recruitment in the pulmonary microcirculation using intravital microscopy in mice.

The paper shows that cytosolic S100A8/A9 is essential for neutrophil adhesion under flow by regulating Ca2+ availability at LFA-1 adhesion clusters.