Author
Medical University of ViennaORCID 0009-0001-3399-4721Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Pawel P. Borowicz, Brian C. Gilmour, Hanna Chan…·Spurkland Anne
This study identifies a specific tyrosine residue in an intrinsically disordered SH2D2A sequence that rewires CD19 CAR signaling and surface expression.
Lukas Schrangl, Florian Kellner, René Platzer…·Janett Göhring
The paper quantifies mechanical forces on TCR:pMHC interactions in CD4+ T-cells, finding low forces that do not affect bond lifetimes, suggesting the immunological synapse stabilizes antigen recognition.
Angelika Plach, Vanessa Mühlgrabner, Aleksandra Rodak…·Johannes B. Huppa
The paper uses live-cell imaging to study TCR:pMHC interactions in anti-viral and autoimmunity settings, revealing differences in synaptic engagement, CD8 co-engagement, and signaling efficiency that define central tolerance boundaries.