The Developmental Transcription Factor TBX3 Physically Engages with the Wnt/β-catenin Transcriptional Complex in Human Colorectal Cancer Cells to Regulate Metastasis Genes
Amaia Jauregi‐Miguel, Simon Söderholm, Tamina Weiss, Anna Nordin, Valeria Ghezzi, Salome M. Brütsch, Pierfrancesco Pagella, Yorick Bernardus Cornelis van de Grift, Gianluca Zambanini, Jacopo Ulisse, Alessandro Mattia, Ruslan M. Deviatiiarov, Elena Faustini, Lavanya Moparthi, Francisca Lottersberger, , Claudio Cantù
This study identifies TBX3 as a functional component of the Wnt/β-catenin complex in human colorectal cancer, showing it modulates metastasis-related transcription through direct protein interactions.
bioRxiv · Dec 18, 2023 · PreprintDevelopmental Biology