Simon Söderholm

This study identifies TBX3 as a functional component of the Wnt/β-catenin complex in human colorectal cancer, showing it modulates metastasis-related transcription through direct protein interactions.

The paper examines single-cell Wnt signaling responses in human embryonic stem cells and finds that Wnt target gene activation varies among cells, showing uncoupling in gene expression patterns.

The paper shows that β-catenin binds different genomic loci over time, leading to cell-type specific chromatin responses termed plastic or elastic during Wnt signaling.

This study identifies FOXQ1 as a bimodal activator of Wnt/β-catenin signalling, functioning through TCF/LEF factors and independent mechanisms.

The paper identifies TBX3 as a tissue-specific component of the Wnt/β-catenin enhanceosome, showing its role in transcriptional regulation and metastasis in colorectal cancer.